産業技術総合研究所とサイダ・FDSの研究成果がJournal of Flow Chemistry誌に掲載されました
産業技術総合研究所 小山恵美子先生、杉山順一先生、Joshua P. Barham先生、則包恭中央先生、阿澄玲子先生によるサイダ・FDS装置を使った研究成果がJournal of Flow Chemistry誌に掲載されました。
Title
A continuous-flow resonator-type microwave reactor for high-efficiency organic synthesis and Claisen rearrangement as a model reaction
Authors
Emiko Koyama, Noriko Ito, Jun-ichi Sugiyama, Joshua P. Barham, Yasuo Norikane, Reiko Azumi, Noriyuki Ohneda, Yoshinobu Ohno, Takeo Yoshimura, Hiromichi Odajima, Tadashi Okamoto
Abstract
We have developed a single-mode microwave reactor for continuous-flow synthesis with various methods of operation. This device measures the resonant frequency and modulates the oscillation frequency accordingly to maintain the maximum electric field intensity in the cavity. It can be operated either using constant applied irradiation power or using new programs which change the electric power (E-GRA) and change the flow rate (Fl-GRA), in order to rapidly screen various reaction conditions. As a model reaction, the Claisen rearrangement reaction of allyl 1-naphthyl ether 1 was rapidly optimized in this device, affording the desired product 2-allylnapthalen-1-ol 2 in high (91%) yield and up to 20 g/h productivity.