Williamson Etherification Williamson エーテル合成


Molbank 20182018(2), M996.

“(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylicc Acid”

Hiromichi Egami , Taira Sawairi, Souma Tamaoki, Noriyuki Ohneda, Tadashi Okamoto, Hiromichi Odajima and Yoshitaka Hamashima

  (E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acetic acid is one of the useful components of liquid crystal materials which can be produced through Williamson ether synthesis by synthesizing 4-hydroxy-cinnamic acid and 5-bromo-1-pentene. Although Williamson ether synthesis is generally slow under conventional external heating conditions, microwave irradiation was effective for significant acceleration of the etherification. Furthermore, we demonstrated the rapid and continuous synthesis of (E)-3-[4-(pent-4-en-1-yloxy)phenyl]acetic acid, using a microwave-assisted flow reactor developed by us, in which the blockage by salt precipitation was suppressed by the continuous addition of an aqueous methanol solution after the reaction cavity.

Equipment information Reactor size: 200 mm, Maximum power: 200 W (SAIDA FDS INC.)


実験結果提供:静岡県立大学 薬学部 濱島義隆先生、江上寛通先生
装置情報:200 mmキャビティ、200W