Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides 不活性化アミド ヒドラジン分解
Org. Process Res. Dev. 2019, 23, 588–594.
“Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process”
Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Shuji Akai, Yoshitaka Hamashima, Noriyuki Ohneda, Hiromichi Odajima, Takashi Ohshima
A study of ammonium salt-accelerated hydrazinolysis of unactivated amides is described. We first studied the reaction mechanism by kinetic experiments and DFT calculations and found that cooperation of the hydrazinium salt and hydrazine is important for promoting the cleavage of unactivated amides. Next, we applied the reaction to a microwave flow process, and the amine products were isolated on a multigram scale.
Equipment information Reactor size: 200 mm, Maximum power: 200 W (SAIDA FDS INC.)