Heterogeneous Mizoroki-Heck Reaction 溝呂木-ヘック反応

Outline

Tetrahedron, 2018, 74, 1810-1816.
https://www.sciencedirect.com/science/article/pii/S0040402018301893

“A practical method for heterogeneously-catalyzed Mizoroki-Heck reaction: Flow system with adjustment of microwave resonance as an energy source”

Tomohiro Ichikawaa, Masahiro Mizunoa, Shun Uedaa, Noriyuki Ohnedab, Hiromichi Odajimab, Yoshinari Sawamaa, Yasunari Monguchia, c, Hironao Sajikia

a Laboratory of Organic Chemistry, Gifu Pharmaceutical University
b SAIDA FDS Inc.
c Laboratory of Organic Chemistry, Daiichi University of Pharmacy

Abstract
  The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N,N-dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange.

Apparatus information Reactor size: 100 mm, Maximum power: 100 W (SAIDA FDS INC.)

概要

 

実験結果提供:岐阜薬科大学 佐治木弘尚先生、第一薬科大学 門口泰也先生
装置情報:100 mmキャビティ、100W、固定化触媒

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