(New!!) アルコールのアセチル化 大量合成 Alcohol Acetylation [9.0kg/day]

反応結果

The Chemical Record (2018).
https://doi.org/10.1002/tcr.201800048

Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor

Péter Vámosi  Keiya Matsuo  Tsuguya Masuda  Dr. Kohei Sato  Dr. Tetsuo Narumi Dr. Kazuhiro Takeda  Dr. Nobuyuki Mase

Abstract
  Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.

実験方法詳細

Supporting Information
(https://doi.org/10.1002/tcr.201800048)

Acetylation reaction of cyclohexyl alcohol

アセチル化_大量合成_反応式2
アセチル化_大量合成_result

実験結果提供:静岡大学 間瀬暢之先生、武田和宏先生、佐藤浩平先生

 

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