(New!!) アルコールのアセチル化 大量合成 Alcohol Acetylation [9.0kg/day]
The Chemical Record (2018).
“Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor”
Péter Vámosi Keiya Matsuo Tsuguya Masuda Dr. Kohei Sato Dr. Tetsuo Narumi Dr. Kazuhiro Takeda Dr. Nobuyuki Mase
Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.
Acetylation reaction of cyclohexyl alcohol