【Batch】Synthesis of organic anion transporting polypeptide imaging agent２ (nucleophilic substitution reaction → Deprotection reaction) 【バッチ】有機アニオントランスポーターイメージング剤の合成（求核置換反応→脱保護反応）
J. Label. Compd. Radiopharm., 59, 565-575 (2016).
Outline
J. Label. Compd. Radiopharm., 59, 565-575 (2016).
DOI: 10.1016/j.tetlet.2022.154010
“Radiosynthesis of novel pitavastatin derivative ([18F]PTV-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure”
Hiroyuki Kimura 1,2 , Yusuke Yagi 1† , Kenji Arimitsu 1,2 , Kazuya Maeda 3 , Kazuaki Ikejiri 3 , Jun-ichi Takano 3 , Hiroyuki Kusuhara 3 , Shinya Kagawa 4 , Masahiro Ono 1 , Yuichi Sugiyama 5 , Hideo Saji 1
1 Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan
2 Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, Japan
3 Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
4 Shiga Medical Center Research Institute, Moriyama, Moriyama City, Shiga, Japan
5 Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, Tsurumi-ku, Yokohama, Japan
Equipment information Reactor size: batch-type microwave reactor, Maximum power: 10 W (SAIDA FDS INC.)
概要
実験結果提供：
京都薬科大学 木村 寛之先生、有光 健治先生
京都大学 屋木 祐亮先生†、佐治 英郎先生
東京大学 前田 和哉先生、Kazuaki Ikejiri先生、Jun-ichi Takano先生、楠原博之先生
滋賀県立総合病院研究所 加川 信也先生
理化学研究所 杉山 雄一先生