現：産業技術総合研究所　Joshua P. Barham先生、静岡県立大学　濱島義隆先生、江上寛通先生によるサイダ・FDS装置を使った研究成果がOrganic & Biomolecular Chemistry誌（https://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob02282h#!divAbstract）に掲載されました。

Title
C-alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

Authors
Joshua P. Barham, Souma Tamaoki, Hiromichi Egami, Noriyuki Ohneda, Tadashi Okamoto, Hiromichi Odajima, and Yoshitaka Hamashima

(反応例：C-alkylation of N-alkylamides with Styrenes and Scale-up)

Abstract
 C-alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g/h product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow.